Our main research interest is on physicochemical characterization of proteins possessing biological functions. Previous research targets on proteins are lens crystallins and snake venom toxins. With the advent of proteomics, my group has broadened the research focus to some disease-related proteomic study such as a global proteomic analysis of proteins expressed by Helicobacter pylori (H. pylori) under various environmental stresses or therapeutic treatments. Recently we have also embarked on a program by using the nematode Caenorhabditis elegans as a model organism to study the structure-function correlation between small heat-shock and lens α-crystallin which has been classified recently as a major heat shock protein with chaperone activity. Thus the on-going research projects carried out in my laboratory can be listed as follows:

1. Proteomic analysis of proteins expressed by Helicobacter pylori under various environmental stresses.
2. Discovery of protein markers useful for diagnosis and prognosis of gastroduodenal diseases.
3. Characterization of alkylhydroperoxide reductase from Helicobacter pylori.
4. Analysis of the effect of Reishi-derived polysaccharide and acetic acid on the life span of Caenorhabditis elegans.
5. Physicochemical study of lens crystallins and biochemical characterization of crystallingenes.
6. Structural and functional characterization of snake venom proteins: Development of venom-based antihypertension and antithrombotic agents.

Grant

  • National Science Council: Study of Cellular Protein Expressions under Oxidative and Mechano-chemical Stresses by Proteomics Approaches: Identification of potential protein markers for gastroduodenal and cardiovascular diseases. (96-2311-B-002-021-MY3)
  • Academia Sinica

Publications of Significant Research Achievements (Academia Sinica)

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